Posted by Jedi on December 1, 2005, at 0:02:46
In reply to Re: Linkadge, posted by linkadge on November 30, 2005, at 22:45:12
> They may work for reasons other than what we had hypothesized. While that is good in the sence that they work, it also opens ones mind to the long term implications.
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> Some people do ok on them long term, and thats good, but we need to keep our eyes on any adverse changes associated with long term use.
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> LinkadgeHi,
From some of the recent research on neurogenesis by antidepressants you may be right on target about the monoamine hypothesis. From my personal experience, some antidepressants do work. Nardil in my case. I do not believe I would be among the living at this point, if that one PDOC years ago didn't have the guts to put me on Nardil. I believe that some of the serious endogenous depressions require medication to have any chance of recovery.The fact that we still don't understand how these medications work after fifty plus years makes me wonder. But we have had the tools to observe the living brain for only a few years. I think better tools, understanding and thus treatment are around the corner.
Before medications became available, lobotomy was the treatment of choice for schizophrenia. In 1936, the Portuguese neurologist Egas Moniz developed a procedure called prefrontal leukotomy, later called lobotomy. In 1949 he earned the Nobel Prize in Medicine for his efforts. I was born in 1957, 49' was not that long ago.
JediArticle on Moniz and lobotomy:
http://nobelprize.org/medicine/articles/moniz/[Neurogenesis: a novel strategy for the treatment of depression]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16222968&query_hl=24Implications of adult hippocampal neurogenesis in antidepressant action.
http://www.cma.ca/multimedia/staticContent/HTML/N0/l2/jpn/vol-29/issue-3/pdf/pg196.pdf
poster:Jedi
thread:582599
URL: http://www.dr-bob.org/babble/20051126/msgs/584020.html