Posted by Tomatheus on December 1, 2005, at 10:07:25
In reply to Zyprexa cognition, posted by AMD on December 1, 2005, at 7:39:33
AMD,
See my responses below...
> I used last Friday. But rather than a steady increase in my mood since then, things are getting worse. I'm more scatterbrained, depressed, and tired today than I was yesterday.
I was on Zyprexa for a few weeks (I think my dosage ranged from 2.5mg to 15mg), and your description basically fits the way I felt on it the whole time. I was originally diagnosed with dysthymia and then diagnosed as bipolar after getting some cycling on Paxil. Since then, I've basically had nothing but dysthymic symptoms that have not responded very well to meds.
What's your diagnosis, and what are your primary symptoms?
> Is it possible it's the effect of the Zyprexa I took yesterday morning and the day before?
Absolutely.
> How long does it take Zyprexa to leave one's system?
I'm not completely sure (but I see that B2chica answered this one).
> Is it possible this is delayed on-set of permanent effects from the alcohol and cocaine use Friday night?
It's possible, but it sounds more like the effects of Zyprexa.
> Would brain damage caused then be exasperated through non-use, or would one expect one's faculties to improve each day?
I can't say for sure, but I would think that if anything, one's faculties would improve with time (once you stop feeling the effects of cocaine withdrawal). But then again, I've never used cocaine, so I'm probably not the best person to answer this.
I do wonder, however, if your cocaine use might have been an unintentional attempt to combat the effects of the Zyprexa. Zyprexa lowers dopamine levels by blocking the D1 and D2 receptors, and cocaine use produces a rapid increase in dopamine (I believe that this is caused primarily by a strong inhibition of the dopamine transporter). I'm not trying to say that you should use more cocaine, but I'm just wondering if you were unintentionally trying to correct a Zyprexa-induced dopamine deficit.
> If there were anything I could take to pull me out of this as soon as possible, what would it be?
I'd talk to your doctor, but I would think that a stimulant would probably be the best thing to (somewhat rapidly) counter the effects of Zyprexa. Of course, if this is the effect that Zyprexa is having on you, it might be better to lower the dose or discontinue it altogether.
Tomatheus
poster:Tomatheus
thread:584109
URL: http://www.dr-bob.org/babble/20051126/msgs/584151.html