Posted by yxibow on December 19, 2005, at 1:22:14
In reply to Calling Racer for equine info :-) » yxibow, posted by ed_uk on December 18, 2005, at 15:02:18
> Hi again yxi
>
> It seems that methocarbamol (Robaxin) is chemically related to meprobamate and carisoprodol. It's interesting to compare their chemical structures.I wish it was more chemically related :)
>
> Do you find that Robaxin makes you drowsy?Possibly the initial dose. Its hard to say, I practice polypharmacy and the Seroquel is probably the most drowsy agent
How much do you take, 1500mg per dose? I guess you need to take it every few hours, it's got a very short half life.
1125 (750x1.5) t.i.d. for a total of 3375 per day. I was at 1500 per dose but there was a possible tachycardia and P450 / serotonin syndrome reaction so we backed off. Robaxin obviously existed before more rigorous drug-drug testing.
>
> Methocarbamol is also known as guaifenesin carbamate. It's a derivative of guaifenesin.
You've been reading Steve Dyer and company... I can't vouch for organic chemistry other than I can see some relation with the structure.
Guaifenesin itself is used in OTC cough medicines in humans and as a muscle relaxant in horses. As far as I know, guaifenesin has been used as an adjunct to anesthesia in horses, to relax muscles.
Curious... I find the stuff almost as bland and unexplainable as Pepto Bismol (I still don't see how a heavy metal salicylate helps the stomach).
> Despite the widespread use of guaifenesin in medicines for chesty coughs, there's little or no evidence that it actually works.Placebo has a 33% value... :)
> Guaifenesin has been claimed to be useful in the treatment of fibromyalgia. Whether it actually works is controversial.Quite controversial... not as controversial as fluoride in the water and other sky is falling things... [no offense to the believers but science doesn't hold much to it]
To be honest, it would make more sense to use methocarbamol because it's got a longer duration of action.And a caution of dose escalation, up to being hospitalized. Although I dearly would love the stuff. (Did I already say that ? :)
Cheers-J
poster:yxibow
thread:589660
URL: http://www.dr-bob.org/babble/20051211/msgs/590293.html