Posted by vbAgent on December 27, 2005, at 22:55:37
In reply to Safe to take Biaxin (anti-biotic) with paxil/dex?, posted by adamCanada on December 27, 2005, at 22:43:15
Taken from Drug Interactions at http://www.drugs.com:
Biaxin and Paxil (moderate Drug-Drug)
Description:
GENERALLY AVOID:
The use of some macrolide antibiotics has been associated with increased blood levels of some selective serotonin reuptake inhibitors (SSRIs), resulting in excessive serotonergic effects or serotonin syndrome. The mechanism is inhibition of the CYP450 3A4 isoenzyme, which metabolizes SSRIs.MANAGEMENT:
In cases where both drugs are necessary, one could consider using a macrolide antibiotic that does not inhibit CYP450 3A4, such as azithromycin or dirithromycin.--------------------
Ask your pharmacist or doctor if it's truly safe. You may need a different antibiotic because Biaxin might potentiate the effects of Paxil.
poster:vbAgent
thread:592639
URL: http://www.dr-bob.org/babble/20051221/msgs/592641.html