Posted by law663 on January 9, 2006, at 19:47:29
In reply to Re: What is the biological pathway... sex and SSRI?, posted by blueberry on January 9, 2006, at 17:58:52
Humm, that's interesting. I'm suprised to hear about zyrexa as it increases prolactin and blocks DA which is needed for sex. I'm skeptical of the prozac claim b/c of the high prevalence of sex side effects with those on it (and it killed my sex drive) [but appeciate the feedback].
I've often wondered what are the effects of raising 5HT levels in all areas of the brain. we already know that it dramatically changes sleep arcitecture.
> As Racer said, the 5ht2c receptor has a lot to do with it. Over the years I noticed paxil gave me profound sexual side effects, but I actually had some pro-sexual side effects on prozac, celexa, and zoloft. It took me a while to figure out why. With paxil, it was the only med I took. With all the others, I was also taking zyprexa, which just so happens to block the 5ht2c receptor. Recently I tried removing the zyprexa, and all the usual ssri side effects came back bigtime. For me anyway, zyprexa blocks most of the serotonin side effects of nausea, insomnia, and sexual dysfunction. And I do believe it has a lot to do with that 5ht2c receptor.
>
> Prolactin was mentioned. If a drug increases prolactin levels, say goodbye to any sex life. Drugs that usually do that are ones that have a stimulating effect on dopamine, but not so much with the ssri's.
>
> I'm certainly no expert, but just passing on what I've experienced myself over the years.
poster:law663
thread:597032
URL: http://www.dr-bob.org/babble/20060108/msgs/597318.html