Posted by yxibow on January 12, 2006, at 12:59:20
In reply to I've noticed that Topamax is interfering w Vicodin, posted by picklehead on January 12, 2006, at 8:55:50
> It's like the Vicodin is just not working anymore. Well, except, of course, for the drowsy side effect (I always get that no matter what :-( Has this happened to anyone else? Does anyone have any suggestions? I just started taking Topamax again for the second time yesterday. The only other thing I take is Vicodin.
Topamax is not known for affecting the P450 system to any noticeable degree, 2D6 is one of the pathways of Vicodin. You may just be experiencing a trace side effect of Topamax, and 1 day of any drug for the most part does not start inhibiting the other unless there is a severe interaction between the two. Of course hydrocodone was create d way before Topamax so we just dont know all the interactions but it seems too soon.
poster:yxibow
thread:598286
URL: http://www.dr-bob.org/babble/20060108/msgs/598358.html