Posted by ed_uk on February 2, 2006, at 12:58:14
In reply to Opium, posted by EERRIICC on February 1, 2006, at 23:06:48
>I personally found no relief from Tramadol, Buprenorphine, Codeine and MSContin. My depression completely evaporates however when I take 10mg of oxycodone. Any idea why this might be?
Have you tried MS Contin at high doses? Morphine's oral bioavailability is often rather low.
Morphine acts as an agonist at mu opioid receptors. Oxycodone is believed to act at mu receptors and kappa receptors. Perhaps oxycodone's activity at kappa receptors is important.
Ed
poster:ed_uk
thread:605357
URL: http://www.dr-bob.org/babble/20060129/msgs/605484.html