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Re: results of placebo v. placebo study » ed_uk

Posted by Larry Hoover on February 5, 2006, at 12:13:44

In reply to Re: results of placebo v. placebo study » zeugma, posted by ed_uk on February 4, 2006, at 12:04:51

> Hi Zeugie
>
> What do you think of this........
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12640329&query_hl=35&itool=pubmed_docsum
>
> Ed

That is just plain bizarre. It was an open trial. The subjects knew the pills were inert. Yet four people dropped out due to adverse effects, and anxiety was reduced by 63%? Amazing.

Being an open trial, however, you have to wonder just how much interaction occurred between the subjects and the doctors. Wanting to please the doctor can be a powerful confound, apart from the placebo aspect. Is there any placebo effect in an open trial?

Lar

 

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poster:Larry Hoover thread:606218
URL: http://www.dr-bob.org/babble/20060205/msgs/606570.html