Posted by linkadge on February 13, 2006, at 20:03:24
In reply to Interesting article in Science about how changes, posted by Pfinstegg on February 13, 2006, at 18:25:20
Note, that BDNF expression in the hippocampus and BDNF expression the neucleus accumbens assert two totally different behavioral effects.
Increasing BDNF in the hippocampus asserts an antidepressant effect, whilest increasing BDNF in the reward centres of the brain asserts a behavioral depressant effect. Its slightly counterintiuitive, but this effect has been repeated in a number of studies.
Antidepressants are thought to work by increasing hippocampal BDNF, not BDNF in the NAA.
Linkadge
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URL: http://www.dr-bob.org/babble/20060212/msgs/609270.html