Posted by linkadge on February 28, 2006, at 8:53:20
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyone? » Phillipa, posted by TylerJ on February 28, 2006, at 0:28:10
To say that they don't work at all may be closed minded on my part. But I wouldn't call somebody an idiot just based on the fact that they dissagree with the efficacy suggested by the drug companies.
A drug would need to keep me away from major depression for at least 6 months before I'd say it had any effect.
Some of the initial effects of a drug may be due to its actions on sleep. We know, for instance that interupting REM sleep in depressed patients has a very acute antidepressant effect. Most antidepressants initally significantly reduce REM sleep. Some of the "most effective" enatidepressants reduce REM sleep the most, ie the MAOI's.
But the body fights back hard. After a few months the body regains its REM sleep. You see drugs poop out a lot around the same time REM rebound occurs.
So I guess what I am saying is that, wait 6 months, and if you are still as enthused about a particular drug, then maybe it is doing something.
And who knows what it is your REM sleep is trying to do. Sure REM sleep is depressing, but maybe it is working on a much more solid an concrete solutions to your problems.
Linkadge
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