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Adjusting the dose

Posted by ed_uk on March 9, 2006, at 18:09:50

In reply to Re: I think there's another point, though » Racer, posted by ed_uk on March 9, 2006, at 13:20:36

In some cases, the excipients in a tablet can affect the bioavailability/absorption profile of a drug. The 'new' Nardil is alleged to be bioequivalent to the 'old' Nardil. It is, however, possible that its bioavailability may be slightly different. If so, it should be possible to re-establish efficacy by adjusting the dose.

Some of the symptoms people have reported when transitioning from the 'old' Nardil to the 'new' Nardil resemble withdrawal symptoms. It is possible that the new formulation may have resulted in slightly lower bioavailability. If this is true, increasing the dose or frequency of administration should help. Why is no one discussing this? The 'new' Nardil is all we have. We must learn to optimise its efficacy and usefulness, rather than dismissing it as useless. It might smell bad.........it might taste bad......but it's still phenelzine: a powerful antidepressant and anxiolytic.

Ed


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URL: http://www.dr-bob.org/babble/20060304/msgs/618043.html