Posted by SLS on March 11, 2006, at 23:37:10
In reply to Re: Many people fear MAOI's.... » SLS, posted by theo on March 11, 2006, at 22:46:19
> Nevertheless, the antidepressant effect of Wellbutrin was quite evident once it was added. Both people take 300mg.
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> > - Scott
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> Which version, regular, SR, XL? Which is more effective?Both people currently take the XL version. One claims that she prefers the SR. The regular version often produces too many ups and downs throughout the day and can lead to dysphoria. The extended release versions are said to be smoother and reported to "feel" more effective by some people.
I've been given samples of the Wellbutrin XL which I am supposed to start taking two days from now. Wellbutrin (regular) has made me feel worse in the past. My doctor would like to see how I respond to it while taking Lamictal at the same time. I guess he wants to see for himself. I am anticipating feeling worse on Wellbutrin XL, despite my never having taken an extended release version or having combined it with the drugs I take currently.
I'll probably end up back on Nardil until something new comes out or when rTMS is approved to treat depression. I'm having a difficult time embracing EmSam (selegiline) as a treatment in my case. I didn't respond to the oral version, and Parnate represents a dead end. Then again... Who knows. A doctor at the NIMH suggested that I revisit selegiline because it is a propargyl derivative, and I once responded to clorgyline, which is also a propargyl MAOI. It's too bad pargyline (Eutonyl), a propargyl selective MAO-B inhibitor, is no longer available. I would have tried it. My guess, though, is that neither selegiline nor pargyline are as broadly effective as Parnate or Nardil. MAO-A seems to be more important when treating severe depression.
- Scott
poster:SLS
thread:618332
URL: http://www.dr-bob.org/babble/20060310/msgs/619168.html