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Benzodiazepines, does it mean tolerance/dependence

Posted by sdb on March 12, 2006, at 16:50:10

It's an old question but I am not completely sure apart from all common pharmacology knowledge.

How are your personal experiences with benzos?

Did you have tolerance to benzodiazepines (which bz, how long, how much, for what)
thus the need to elevate the dosage from time to time for the same effect or did you have no problems with tolerance?

Did you have dependence (which bz, how long, how much, for what)
, you were not or almost not able to taper down the benzodiazepine or did you have no or almost
no problems with dependence?

There are possible differences between benzos metabolizing in nordazepam eg. Valium
and other benzos like Xanax xr (alprazolam), Klonopin (clonazepam).

Thanks for every personal experience, response, thought, knowledge...

~sdb

Short list of benzodiazpines from wikipedia:

Triazolam (Halcion®) - 2 hours
Midazolam (Versed®, Hypnovel®) - 3 hours (1.8-6 hours)
Oxazepam (Serax®) - 4-15 hours
Chlordiazepoxide (Librium®) - 5-25 hours
Alprazolam (Xanax®) - 6-12 hours
Temazepam (Restoril®) 8-20 hours
Lorazepam (Ativan®) 10-20 hours
Loprazolam (Dormonoct®) 10-20 hours
Bromazepam (Lexotan®) 10-20 hours
Estazolam (ProSom®) 10-24 hours
Clobazam (Frisium®) 18 hours
Flunitrazepam (Rohypnol®) 18-26 hours. Withdrawn from the market in some countries; considered a "date-rape drug"
Clonazepam (Klonopin®, Rivotril®) 18-50 hours
Nitrazepam (Mogadon®) 20-40 hours
Quazepam (Doral®) 25-100 hours
Clorazepate (Tranxene®) 36-100 hours
Medazepam (Nobrium®) 36-150 hours
Nordazepam (Madar®, Stilny®) 50-120 hours
Prazepam (Centrax®) 36-200 hours
Diazepam (Valium®) 36-200 hours
Flurazepam (Dalmane®) 40-250 hours


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poster:sdb thread:619438
URL: http://www.dr-bob.org/babble/20060310/msgs/619438.html