Posted by Questionmark on March 14, 2006, at 4:30:53
In reply to Re: Abstract-- (MAO-A vs. MAO-B, dopamine), posted by gibber on March 13, 2006, at 21:22:33
> I can't address your question as a whole because I just don't know, but I did want to point out one error in your arguement. Phenylalanine is not converted to phenylethylamine by MAO-B. This must be catalyzed by a different enzyme. MAO-B instead quickly breaks down phenylethylamine, so taking a MAO-B inhibitor will allow PEA to accumulate. Note: I'm taking DLPA and 10mg of selegiline right now and not noticing any strong antidepressive qualities yet.
Yes, i'm glad you pointed that out. I actually realized the error in that shortly after (or maybe the day after) writing & posting it when i read an abstract in which they administered oral phenylethylamine with 10mg (i think) selegeline so that, as it said, it would not be immediately metabolized (is this incorrect to say "metabolized" and not "catalyzed"?) by MAO-B in the body. i was going to go back and write a brief "Correction" post, but i did not get around to it. But that's okay cuz you did basically. So, thank you.
Wait a minute, i have a question. Is phenylethylamine ever present long enough to have effects in the body when MAO-B is not being inhibited? i mean i automatically assume yes but how if it is metabolized so quickly when ingested (or when formed in the body, if it is formed in the body)?By the way, what willyee said in his post is interesting. That could be pretty significant.
i'd really like to get some liquid deprenyl and try it at very low doses for awhile.
poster:Questionmark
thread:619679
URL: http://www.dr-bob.org/babble/20060310/msgs/620108.html