Posted by MARTY on March 23, 2006, at 15:48:44
In reply to Re: Nardil_MAOI + Buspar = Danger or simply suicidal ?, posted by JaclinHyde on March 23, 2006, at 13:59:58
Thank you both for your post.
Scroll down for my replies ..
---= Interesting PDoc chat about Sex.Side effect Antidotes =---
http://www.dr-bob.org/tips/split/SSRI-sexual-dysfunction.html
---= A partial list of Antidotes
There are many possibilities: Amantadine, Bethanechol, Bupropion, Buspirone, Cyproheptadine, Dextroamphetamine, Methyphenidate, Mirtazapine, Nefazodone, Neostigmine, Yohimbine. Results on each of these varies. A physician can check "Sexual Pharmacology: Fast Facts" by Robert Taylor Segraves, MD and Richard Balon, MD for dosage).
---=Linkage >> You are right on one point: Buspar isn't causing Serotoninergic Syndrome.
After redoing my homework on google I've found out that I've missed a very importance statement in the Nardil Pfizer doc .. it says clearly that the risk with BusPar is related to Hypertensive Crisis. PS: BusPar increase Serotonin when it agonize pre/post 5-HT1a; those receptors not only will they produce Serotonin but they will stimulate (I'm sure how) the totality of the Serotonergic systems. 5-HT1a is the only receptor to have this powerfull caracteristic.JaclinHyde >> I didn't know that. But what I know is that for 1 person that likes BusPar there are 5 persons that hated it. While I put my money on the 5 ones, I may continue to take BusPar (in the event I conclude that the benefit is worth the risk).
The reason is that I try to design a cocktail that will reduce very significally the sexual side effect of the Nardil (and Risperdal). In the literature that discuss the known 'antidotes' for S.Dysfonction caused by Antidepressant, Buspar is coming back very often.
There are 3 things to look for in a ADSDA (Antidepressant Sexual Dysorder Antidote):
Antagonisation of the infamous 5-HT2c receptors, dopamine receptors agonism, cholinergic agents.1* Have you ever try one of the Antidote for Antidepressant induced sexual disorder ?
2* If you would be in my place, would you try BusPar in trying to save your sexual life (and couple!?)
(Nardil + Buspar = faster, stronger hypertension)
Hope your well,
Marty
poster:MARTY
thread:623581
URL: http://www.dr-bob.org/babble/20060322/msgs/623752.html