Posted by SLS on March 23, 2006, at 20:37:55
In reply to SSRI's indirectly influence DAT (negatively ?), posted by linkadge on March 23, 2006, at 19:34:22
> http://www.nature.com/cgi-taf/DynaPage.taf?file=/npp/journal/v28/n2/full/1300036a.html
>
>
> LinkadgeIt looks like a negative feedback loop to me.
Maybe increased 5-HT inhibitory outflow > reduced DA activation > reduced synaptic DA > upregulation of DAT and postsynaptic receptors = improved DA signal-to-noise ratio?
Perhaps this helps to account for antidepressant discontinuation rebound improvement/mania.
Just a thought.
- Scott
poster:SLS
thread:623866
URL: http://www.dr-bob.org/babble/20060322/msgs/623903.html