Posted by TylerJ on March 24, 2006, at 9:36:45
In reply to Racer: is Trazadone an NRI?, posted by greywolf on March 19, 2006, at 22:10:00
>
> Most of the info I've read says Traz is an NRI, but I've seen a couple studies that reject the proposition. One found that Traz does not inhibit NE reuptake, but may enhance NE release. But the bulk of the reports accept that Traz inhibits NE.
I'm not Racer, however I'm taking Trazodone so I'll tell you what i know about it. Traz is a Triazolopyridine with a 1/2 life of 4 - 9 hrs. Traz inhibits presynaptic serotonin, and has mild postsynaptic serotonergic antagonism. It is also a potent antihistamine which causes it's sedation effect and possible weight gain. Traz also causes marked inhibition of alpha-1-adrenergic receptors which can lead to severe hypotension. For me, 200mgs. at bedtime helps tremendously for my moai induced insomnia. Any more than 200 causes daytime drowsiness for me.Tyler
poster:TylerJ
thread:622029
URL: http://www.dr-bob.org/babble/20060322/msgs/624126.html