Posted by MARTY on March 26, 2006, at 4:29:46
In reply to Re: Opiate receptors - dopamine receptors, posted by SLS on March 25, 2006, at 23:16:49
My guess after reading those 2 abstract is that those scientists would not refuse a copy of that 'opioid-dopaime interactions for dummy" ;)
It looks like a very complicated sphere of research even in 2006.For what I understand the abstract propose many hypotesis at multiple level of action.
If I got to retain a simplified and simplistic version ...
1- Induces the release of endogenous opioid peptides. (but how?)
2- Those opioid peptides increasing opioidergic activity via mu-opioid receptors in the ventral tegmental area (VTA) and delta-opioid receptors in the nucleus accumbens (NAcc).
3- Having the effect of inhibe the GABAergic neurotransmission.
4- Which disinhibite some dopaminergic neurons; facilitating dopamine release in the (A, B Mesolimbic, NAcc) regions of the brain.
5- Those specific dopaminergic release reward the ethanol user and (mesolimbic dopamine release) is implicated in the brain learning of the stimuli (appreciation->dependence)
Thanks for the abstract Scott.. very interesting stuff!
Cheers,
Marty
> Some of this stuff confuses me. I don't know enough about the opioid system to understand all of the opioid-dopamine interactions depicted in the abstracts I cited.
>
> I wish there were one of those "Dummies" books for understanding the CNS.
>
>
> - Scott
poster:MARTY
thread:624512
URL: http://www.dr-bob.org/babble/20060322/msgs/624747.html