Posted by linkadge on March 28, 2006, at 11:12:48
In reply to Re: amotivational syndrome, posted by SLS on March 28, 2006, at 7:02:01
The 5-ht2c receptors are also important. Agonism at 5-ht2c will reduce dopamine release in the frontal cortex and in the neucleus accumbens.
Zyprexa may offer some help as it is an antagonist at 5-ht2a/c receptors, but part of the problem is that even if it does allow for increased dopamine release, some of that dopamine will be blocked via its d1/d2 antagonism.
I found that periactin (antihistamine with 5-ht2a,c antagonism), was as good as zyprexa for reducing SSRI apathy, but it may be hard to get nowadays.
I think the big thing is that with the SSRI's you are going to get decreased frontal cortex dopaminergic function. OCD may have overactive frontal cortex dopamine, and may be why they help in these instances.
The problem with apathy, is that when it strikes, you don't really care !!
Zoloft and periactin was a good combination,
the periactin had a short half life and needed to be taken a few times a day.
Linkadge
poster:linkadge
thread:624520
URL: http://www.dr-bob.org/babble/20060322/msgs/625490.html