Posted by gibber on April 1, 2006, at 13:39:13
In reply to Re: EMSAM-YEAH. SELEGINE-NOT SO GOOD. uh!??, posted by rod on April 1, 2006, at 5:30:02
I don't think the patch will avoid any side effects caused by the metabolites. The drug will still endup at the liver at some point to be metabolized. The advantage I think will come from not having the typical curve of drug concentration in the blood during the course of the day. It will be a steady stream of drug which may minimize the metabolite concentrations at any one time. I think insomnia was still a bit of problem for Adam while he was on the patch, but had a greater problem with it while taking the tabs. I don't think people who are on selegiline are really taking a high enough dose. I've read that 30-60mg is an antidepressant dose. I'm at 20mg of the tab and not seeing too much relief. There is no sense is saying that EMSAM is bad or good at this point. Its another case of what works for one doesn't for the other. Some people in the studies did really well on it and some did not. Studies don't reflect real life however. This is really a wait and see situation and of course that blows. Wouldn't it be nice to know a drug is coming out that is guaranteed to work...maybe in a hundred years.
poster:gibber
thread:627408
URL: http://www.dr-bob.org/babble/20060329/msgs/627501.html