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Re: melatonin, REM, Parkinson's disease » zeugma

Posted by linkadge on April 1, 2006, at 15:39:44

In reply to Re: melatonin, REM, Parkinson's disease » linkadge, posted by zeugma on April 1, 2006, at 14:17:15

Yeah that is true. Norepinephrine seems to control hippocampal timing, or oscilations or something like that.

But I think that in certain situations norepinephrine is anticonvulsant and in others it is proconvulsant. The thing is that most current NRI's have some proconvulsant activity.

All the TCA's and venlafaxine can be proconvusant in certain situations, but whether this is attributable to their effects on norepinehprine is unclear.

Lithium can be both proconvulsant and anticonvulsant. Lithium seems to increase the
ability of cholinergic agonists to induce seizures, yet it can still tame mania, so I don't know if mania and seizures are always directly comparable.

But on the other hand, we use ECT to treat depression.

I think that if you induce a seizure below certain threshold it can increase the seizure threshold. I know that ECT can increase the seizure threshold, and so can rTMS.

Then there is a big overlap between epilepsy and depression.

Linkadge


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