Posted by iforgotmypassword on April 8, 2006, at 16:24:08
In reply to Re: how do you *increase* cingulate cortex activit » iforgotmypassword, posted by SLS on April 8, 2006, at 12:01:37
sorry, passed out again. hmm, interesting link. it's kind of scary that the even with the blood flow increases, the glutamate release starts causing problems. but that's ketamine, and could just be showing what an extreme of the nmda-antagonist idea could cause? jay a. goldstein did seem to focus a lot on how nmda receptor antagonism is helpful, and used lowered dose ketamine for results (this is for CFS, but also relates to his theories of cognitive salience which is very interesting). akwardly, i haven't heard much about amantadine though, other than marginal short term benefit, so i always worry if it is really a serious nmda receptor inhibitor, and doesn't just cause an initial reaction due to some level of dopamine release. i guess then there's memantine, but it's hard to get in canada unless you have alzheimer's apparently. do you know much about amantadine and it's activity?
my reasoning isn't very solid, except in the sense that hoarding is a huge problem i have in every aspect, so i figure maybe a lot of my problems are rooted in similar neurochemistry. (the symptoms underline endless indecision, churning thoughs through your mind, inability to do things and assess what changes mean and not resist, and just awkward behaviour that i epitomize) OCD not so much in my case (OCPD yes, though)... but apparently it seems to be a distinct symptom and neurological profile from OCD (which seems to be showing why SSRIs and clomipramine have little luck affecting hoarding) UCLA was doing a study on galantamine (Razadyne, formerly Reminyl), but i don't know what happened to it. :(
(sorry for the poor phrasing.)
poster:iforgotmypassword
thread:630544
URL: http://www.dr-bob.org/babble/20060408/msgs/630629.html