Posted by SLS on April 14, 2006, at 12:30:02
In reply to Oups bad title.. post for everyone, posted by MARTY on April 14, 2006, at 12:11:56
Hi Marty.
The problem is this: These drugs do more than just attach themselves to the MAO enzyme. Unfortunately, there is no real incentive to elucidate exactly what these things are, but it is obvious that Parnate acts very much like a stimulant. It can produce an amphetamine-like effect at 10mg almost immediately. This is too low a dosage and too soon to inhibit a significant amount of MAO. So we have a drug that might act to release or inhibit the reuptake of norepinephrine. Whatever it does, it tends to cause spontaneous hypertensive reactions in some people. If introduced at a time when there is already significant MAO inhibition, there might be a synergism that results in a serious adverse event.
I like your theory, though.
- Scott
> Sorry this post wasn't only for Linkage like my title was saying...
>
> What do you think of this theory:
>
> The monoamines oxidase level is returning to is normal level after 3-5 days. For this theory lets be more conservative/safe and let's say 10 days.
>
> My pdoc think that because Nardil and Parnate works in the same way, stoping a MAOI and starting another should not be a problem since it should not change a lot the MAO level.. letting some MAO in the body which is important since a person with a level of 0 MAO is in big trouble.
>
> But here's my theory: Nardil and Parnate doesn't inhibit the MAO-A and MAO-B in the same proportion. Here's an exemple of the problem that it could cause: If one day after stoping Nardil, which let's say BY EXEMPLE inhibit 75% MAO-A and 25% MAO-B, I start Parnate who would BY EXEMPLE inhibit 25% MAO-A and 75% MAO-B.. I would have in theory, depending on the dose of Nardil and Parnate and etc.. near not much MAO since N-MAO-A 75% + P-MAO-A 25% = MAO-A 100% and N-MAO-B 25% + P-MAO-B 75% = MAO-B 100% ...
>
> Those numbers are fictional and have been picked just to simplify the explanation of my theory.
>
> Anyone thinks it could make sens ?
>
> Thanks for your time and hope you are all well.
> Marty
>
>
poster:SLS
thread:632778
URL: http://www.dr-bob.org/babble/20060412/msgs/633068.html