Posted by yxibow on April 26, 2006, at 19:30:08
In reply to Re: Klono depressing. Need long benzo not depressi » yxibow, posted by valene on April 26, 2006, at 8:19:23
> Jay,
> According to the benzo equivalency chart on Dr. Bob's site, xanax has a half-life of 9-20 hours! Here is the link:
>
> http://www.dr-bob.org/tips/bzd.html
>
> Best wishes, Val
>
> > > I prefer xanax as a benzo. For me it seems to have a half-life of about 18 hours. I found valium very depressing and have heard that K is also. Best wishes, Val
> >
> > Interesting -- alprazolam usually has a 4-6 hour half life and requires 3-4 times a day dosing. So our metabolism I guess is a case against XanaxXR :)
> >
> > Cheers
> >
> > -- Jay
>
>Those take in account all metabolite half lives and are really "in vitro" lab half lives, not "in vivo" (human and post marketing trials).
Xanax is notoriously known for an actual 4-6 hour half life in individuals requiring up to 4x daily dose were it to be used ongoing, only preceeded by things like Halcion and Rohypnol with true half lives of around 1-2 hours.
Xanax is still best used in most people as PRN or for breakthrough anxiety as its absorption to plasma level is very short and it is one of the benzodiazepines which can develop a greater habituation due to its short half life.
poster:yxibow
thread:636282
URL: http://www.dr-bob.org/babble/20060423/msgs/637318.html