Posted by linkadge on May 1, 2006, at 19:14:32
In reply to Animal models of psychiatric illness, posted by ed_uk on May 1, 2006, at 16:36:15
I agree in some sences. It makes me feel bad to be compared to a rat.
In other sences though, many of the drugs that are active in the forced swim test seem to correspond to human efficacy.
For instance, ECT is effective in animal models, as is rTMS. Even access to wheel running is active. Brain growth factor injections are active, and so are CRH antagonists etc, NMDA antagonists, dopamine agonists, SJW, SAMe, etc.
Agents that induce the greatest increase in BDNF in certain areas of the brain seem to confer the most effect in the forced swim test.
Triple uptake inhibitors seem to also be much more active than either SSRI's or TCA's, at least from some of the preliminary reports.
I think imipramine is superior to SSRI's in the forced swim test, and in human depression it is arguably superior to SSRI's as well.
I think in some ways we are rats. I think we respond to pain and pleasure the same ways.
Yeah, I know, its controversial.
Linkadge
poster:linkadge
thread:638491
URL: http://www.dr-bob.org/babble/20060429/msgs/638962.html