Posted by Larry Hoover on May 15, 2006, at 23:09:36
In reply to Re: Loratadine for SSRI's sexual dysfunction, posted by Caedmon on May 15, 2006, at 22:41:16
> I don't believe cyproheptadine is contraindicated with MAOIs. In fact, I believe it's very often used in the management of serotonin syndrome secondary to MAOIs and other serotonergic antidepressants.
That's good news.
> I'm a little surprised to hear of loratadine for sexual dysfunction. I understood that the benefit of this drug was that it was an antihistamine, but that it would be *less* apt to cross the blood-brain barrier vs. first-generation antihistamines? Seems a convoluted way of achieving such a goal.
>
> - ChrisThe theory, as I understand it, is that loratadine changes the effects in the periphery, rather than centrally. It influences specific serotonin receptors that are in the genitals, protecting them from unwanted effects caused by peripheral SSRI activity.
Lar
poster:Larry Hoover
thread:644267
URL: http://www.dr-bob.org/babble/20060515/msgs/644563.html