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focalin chemistry and pharmacology

Posted by saturn on May 24, 2006, at 22:07:38


My understanding is that focalin (dexmethylphenidate) is the d-isomer of racemic methylphenidate, and it is the one primarily responsible for ritalin's therapeutic effects.

Is the other isomer l-methylphenidate?

And is methylphenidate similar to amphetamine where the D-isomer is primarily centrally acting and the other (stereo)isomer is primarily active in the PNS (peripheral side effects)?

I read somewhere that the centrally-inactive isomer of methylphenidate, which is cut out of focalin, is actually poorly absorbed and so even with ritalin it is mainly the dexmethylphenidate that is absorbed. Could anyone comment on this? Thanks,

Regards

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