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Re: Can you have ADHD with BIPOLAR? » detroitpistons

Posted by linkadge on May 26, 2006, at 16:58:18

In reply to Re: Can you have ADHD with BIPOLAR? » linkadge, posted by detroitpistons on May 24, 2006, at 15:29:15

Intersting. I think Dr. Manji (who does a lot of research into bipolar and some in ADD) was the one who reported finding abnormalities in the frontal corticies of bipolars (and those with family history of unipolar). He said there was a significant reduction in glia (I believe) in SG-25.

Anyhow, it seems to suggest that the problem is perhaps more structural and less biochemical. I suppose stimulants and such can work to boost the activity in whatever circutry exists.

His findings also seemed to show that treatment with lithium or valporate (but not other mood stablizers or antidepressants) seemed to reverse atrophy in this area.

Both lithium and valproate (but not other drugs) increased BDNF and BCL-2 in this region.


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