Posted by ed_uk on May 28, 2006, at 13:58:13
In reply to Re: Trouble urinating on various meds?, posted by Reggie BoStar on May 25, 2006, at 5:17:29
Hi
Cymbalta causes urinary retention because it inhibits the reuptake of norepinephrine. This leads to overstimulation of alpha-1 receptors in the the urinary tract. The result is an inability to urinate because the outlet of the bladder is so tightly contracted.
Tamsulosin (Flomax) is a selective alpha blocker. It relaxes the muscles which constrict the outlet of the bladder. Since you're taking Cymbalta, a high dose might be necessary. The standard dose of Flomax is 400 mcg per day. My guess is that you might need 800 mcg.
Alfuzosin (Uroxatral) is another effective alpha blocker. If Cymbalta has elevated your blood pressure, doxazosin (Cardura) might be a good alternative because it reduces BP as well as facilitating urination.
Take care
Ed
poster:ed_uk
thread:647258
URL: http://www.dr-bob.org/babble/20060525/msgs/649748.html