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Re: Desperate here..opinions on Chloral Hydrate Please

Posted by silvercoin on July 18, 2006, at 13:58:32

In reply to Desperate here..opinions on Chloral Hydrate Please, posted by Crazy Horse on July 18, 2006, at 10:23:27

> Insomnia probs...UGH. Lunesta and Ambien don't work. Serequel frightens me because of the possibility of developing TD. Current regimine is Trazodone 250 mgs. at bedtime, also take Klonopin 1.5 mgs at 6:00 and 1/4 mg of ativan at bedtime. Prob is i've developed tolerance to benzos over the past 26 years.
> Soooooooo..a friend of mine swears by Chloral Hydrate. Is it a Benzo? And what do you think of it for my EMSAM 6 mg. induced early morning wakening? This is the only side effect i am getting from EMSAM, otherwise i love it! Please offer your suggestions and opinions. Thanks!
>
> Monte


The chances of developing TD from Seroquel, particularly a low dose for sleep, is so close to zero it is not even worth thinking about. It is nearly as risk free in this regard as clozapine, considered to have the lowest rate of EPSEs among antipsychotic drugs.

I have actually tried chloral hydrate myself during a period of severe depression and extremely severe insomnia (due to withdrawal after a high dose Halcion regimen that induced dependency and mania), and it had no effect, but nothing else at that time worked either. It is reputed to be a powerful hypnotic, though. It is not a benzo but is actually more similar to alcohol and is thought to exert its therapeutic effects through a trichloroethanol intermediate, or somesuch thing. However, it does work on the GABA system as do the benzos, and it apparently has a fairly substantial dependency/tolerance potential. My regular Walgreen's did not stock it, and I was directed to another one, where I had to cough up a $50 copay, as this is a Tier 3 drug for United Health for some reason or another. The cost would not have bothered me if it had actually worked, so bad was my insomnia.

Todd


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