Posted by Jost on July 18, 2006, at 19:50:07
In reply to Re: 1/2 an emsam patch - both types of mao inhibit » Donna Louise, posted by SLS on July 17, 2006, at 9:56:39
> > > > I know that the 6mg patch is equivalent to 40mg dose of selegiline.
> > >
> > > Where can I find more information on this?
> > >
> > >
> > > - Scott
> >
> > Scott, it is all in the whatchacallit that comes in the package with the drug. PI sheet? There is a graph too. I don't know where the idea that 6mg =40mg. According to this package info, transdermally you get about 3 1/2 times the amount you get orally. So, 6mg orally=20mg transdermally. 9mg=30 and 12mg=40. This is why I didn't get the most relief until 12 mg patch as it takes 40mg for me to get enough MAOI A deanimation.
>
>
> I looked at the drug monograph PDF from BMS and on rxlist.com, and couldn't find anything that addressed my question. This issue is really bugging me. I am getting the impression that the 12mg/24hr patch is giving you a plasma level of selegiline that is quite a bit higher than that you would receive from taking a 40mg oral dose.
>
> You would think that you could find a bunch of stuff on Medline stating quite simply what the relative pharmacokinetics are between the two preparations, but you can't.
>
>
> - ScottI thought about posting to the effect that I'm pretty sure, in retrospect, that my pdoc said something about doing the math and coming up with 40 mg in the 6/20 mg patch. But I can't figure out how he got that, after reading through the materials, which are really confusing.
Is it possible they really don't want to commit about how much you're getting compared to oral selegiline? If so, I can't figure out if it could be because the drug seems to be metabolized, and or to have effects that aren't precisely in proportion to what you would think, based solely on the amount in the patch. Or, if it's because there's so much variation in how individuals metabolize it, and there's all this controversy about maoi food effects, that they don't want to go on record with a number, even though they've shown that it's safe, in effect, by the use of tyramine challenges.
But the 40 mg figure really does ring a bell--
Jost
poster:Jost
thread:666394
URL: http://www.dr-bob.org/babble/20060717/msgs/668107.html