Posted by linkadge on July 18, 2006, at 19:59:43
In reply to Re: couldn't have said it better myself, posted by SLS on July 17, 2006, at 22:01:03
"Currently marketed antidepressants work significantly better than our most recent clinical trials indicate"
In your opinion. My opinion is that they work significantly worse, seeing as that trial may just be the first one in 10 that shows the drug performed better than placebo. Drug companies do not have to disclose failed drug trials.
Even if the placebo response was to increas slightly, there are still a whole host of miserable drug responces. Its not unheard of to get large trials showing only 35% of people respond to the active drug.
There is an argument too that trial data from 3 decades ago isn't too relyable, this is evidenced by the fact that some of the initial results for the TCA's have been hard to replicate.
I would still argue that antidepressants may produce impressive initial results owing to their ability to quickly reduce REM sleep.
Thats why you get all those accounts of people saying, "the world looked so much brighter".. thats an effect of REM sleep reduction. It usually subsides as the cholinergic system attempts to regain sensitivity.
Linakdge
poster:linkadge
thread:662854
URL: http://www.dr-bob.org/babble/20060717/msgs/668113.html