Posted by Crazy Horse on July 30, 2006, at 21:19:54
In reply to Re: EMSAM insomnia solution, posted by Jost on July 30, 2006, at 20:49:29
> What, if any, is the relationship between pregabalin and gabapentin?
>
> I'm so interested that you take so much in the morning and only 50 mg at night.
>
> How does it work, and what's the theory behind the dosing?
>
> Jost
>
>
Lyrica (pregabalin) is like a new improved Neurontin..works slightly differently and has a longer half life. For me i could never "feel" neurontin doing anything for me. Lyrica..oh yea, i can feel it working! Studies ( i don't have any references..sorry) indicate high dose Lyrica 500 mgs. plus acts as a mild stimulant. My Pdoc says a large dose all at once in the morning(for me 500 mgs.) works better than spreading it out throughout the day. Some go as high as 1200 mgs. It has a pro gabenergic effect at 500 mg plus. FOR ME, at 500mgs. built up over a couple of weeks increases my energy, stabilizes my mood, has made me very pro-social, and eliminated (perhaps along with EMSAM 9mgs.) my depression. And 50 mgs w/200 mgs. of Trazodone at night works great for sleep..for me anyway (before adding the lyrica, Traz alone wasn't enough). I just feel so damn good right now..it's really almost unbelievable. BUT, this has only been for 3 days, and i have had other meds work really well at first i.e.,Parnate, then poop out, so i'm being cautious and don't want to claim "i am healed!" just yet because it is WAY TO EARLY to see if this is going to last. Anyway that's my story :) I'm just hoping and praying it lasts!!Monte
p.s. as far as sleep..taking small dose Lyrica makes most people sleepy (me included) so this is why the low dose at night. High dose as i stated is stimulating..strange, but true for me.
poster:Crazy Horse
thread:671745
URL: http://www.dr-bob.org/babble/20060724/msgs/672143.html