Posted by notfred on September 28, 2006, at 18:50:56
In reply to Anna Nicole's son's death..., posted by saturn on September 28, 2006, at 18:15:51
SSRI + Methadone:
Possible elevations of SML due to variable
inhibition of CYP450 enzymes (Begre et al. 2002;
Batki et al. 1993; Bertschy 1996; Eap et al. 2002;
Hamilton et al. 1988, 2000; Levy et al. 2000;
Richelson 1997)Warning: Acute increases in serum methadone concentration may produce significant signs/symptoms of methadone overmedication,
possibly resulting in overdose. Recent data suggest that in susceptible individuals acutely elevated methadone levels – alone or, more
commonly, in combination with other drugs and/or cardiac risk factors – may influence cardiac rhythm disturbances (prolonged QTc
interval and/or torsade de pointes; see Leavitt and Krantz 2004
poster:notfred
thread:690014
URL: http://www.dr-bob.org/babble/20060927/msgs/690027.html