Posted by ace on September 29, 2006, at 0:50:35
In reply to Pros and Cons of Seroquel low dose, posted by Phillipa on September 28, 2006, at 23:07:06
> Well my Daughter is taking low dose seroquel for high anxiety. How is it different from a benzo. Thanks Phillipa ps she's on 50mg with zoloft 50mg.
1. Difference between Seroquel and a typical benzo: BIG difference: Seroquel is from a chemical class called dibenzothiazepine derivatives. The mode of action is Seroquel's partial activation of the 5HT1A receptors in the prefrontal cortex of the brain. It has affinity for D2 (DOPAMINE) receptors in the brain (esp Limbic system.
On the other hand, Benzo's INHIBIT action potentials, thus relaxing motor action.These effects result from Benzodiazepine’s modulation of GABA, the main inhibitory neuroansmitter of the CNS, by influencing the GABAA receptor complex.
For high anxiety I would personally recommend Xanax, titrated up to 4mg/day in divided doses.
Although i think antipsychotics, in the vast majoruity of patients are benign and devoid of many s/effects (even wuith long term use at therapeutic doses), its probably safer to scrap the seroquel.
I would also remove Zoloft and add on a TCA or MAOI. I have reservations about the newer cash cows SSRI's. Their efficacy is questionable.
I would try
Nardil- 60-90mg + Xanax 4mg
or
Clomipramine 100mg + 4mg Xanax/1mg Klonopinmany many many other options!!!!!!!!!
Luv
Ace
poster:ace
thread:690091
URL: http://www.dr-bob.org/babble/20060927/msgs/690110.html