Posted by SLS on October 5, 2006, at 18:21:34
In reply to Re: **CORTISOL** » SLS, posted by sregan on October 5, 2006, at 16:33:30
> > Using either mifepristone or dexamethasone for brief, paroxsysmal, one-week courses of treatment probably acts to stress the system into changing gene expressions that control relevant receptor sensitivities, second messenger events, and secretory responses.
>
> Scott,
>
> When a neuro-receptor is blocked the effect is immediate. If you block NMDA then you feel less anxious. With the HPA negative feedback I get confused on what is doing what. A glucocorticoid receptor antagonist should INCREASE circulating glucorticoids because if the receptors are blocked then the monitoring mechanism thinks they are LOW and need to be increased? So it actually increases CRH->cortisol?
Exactly. I would expect adrenal exhaustion as a possibility if treatment were continued for too long. I'm not sure, though.
- Scott
poster:SLS
thread:558802
URL: http://www.dr-bob.org/babble/20061003/msgs/692164.html