Posted by linkadge on November 4, 2006, at 13:48:00
In reply to Re: My first one worked..., posted by qbsbrown on November 3, 2006, at 22:36:02
We do not know that they work via serotonin uptake inhibition.
The reason being that we have agents that are capable of inhibiting the uptake of serotonin with no antidepressant potential. We also have agents like tianeptine that are serotonin uptake acellerators which are just as effective as SSRI's.
Common denominators? All of the SSRI's enhance the action of the potent gabaergic neurosteroid alloprenanaolone. Certain SSRI's and tianeptine also have analgesic/opioid like activity.
So, in total I don't think we have a clue.
Linkadge
poster:linkadge
thread:700174
URL: http://www.dr-bob.org/babble/20061104/msgs/700321.html