Posted by SLS on November 22, 2006, at 8:10:38
In reply to Re: Nardil - hopeful » SLS, posted by tensor on November 22, 2006, at 7:22:06
> >It stated that the increase in blood levels of Wellbutrin were substantial: + 75-150% change in exposure to the drug. I guess it makes sense to begin at 75mg and increase gradually from there.
>
> Ouch! Thanks for that info, we have only Zyban 150mg here. So I guess I will have to take the Remeron+Zoloft path after all.
No, no, no!Don't let that stop you. 150mg might be exactly the right target dosage of Wellbutrin when combined with Zoloft. It might even be too low for you. 300mg is the most common effective dosage when used monotherapeutically. Treatment with Wellbutrin or Zyban is actually initiated at the target dosage of 300mg. With Zoloft, I doubt you would need to reduce that by more than half, so you should be okay at 150mg. You should cut the tablets in half and take 75mg twice a day, as Zyban is equivalent to Wellbutrin SR (not XL). I do know someone who combined Zoloft with Wellbutrin 300mg without a problem. People metabolize drugs differently. If it were me, I would split the pills and titrate to 300mg if I did not respond to lower dosages.
- Scott
poster:SLS
thread:706075
URL: http://www.dr-bob.org/babble/20061117/msgs/706105.html