Posted by Squiggles on December 2, 2006, at 19:39:02
In reply to Re: Maybe all drugs are like this » linkadge, posted by naughtypuppy on December 1, 2006, at 10:43:41
> I read somewhere that about 10% of people that stop Parnate, find it effective and then restarted it at a later time had found that it had lost it's effectiveness. IMHO this is absolutely true. I found Parnate to be the best AD that I had tried so far, but had to discontinue because of allergic reactions. I went back on it several months later with the addition of very powerful antihistamines to combat the allergic reactions but the Parnate had lost all it's effectiveness. I see no obvious reason to belive that this would not occure with other medications as well.
>
>I am sceptical about this idea as applied to more
than your experience. Take a look at this:From PubMed:
ABSTRACT:
1: Drugs. 1996 Apr;51(4):552-70. Related Articles, Links
Causes and problems of nonresponse or poor response to drugs.
Salva Lacombe P, Garcia Vicente JA, Costa Pages J, Lucio Morselli P.
Clinical Pharmacology Department, Uniersity Hospital, Germans Trias
i Pujol, Badalona, Spain.The lack of (or poor) response to drugs has very important medical,
social and economic consequences today. An unsatisfactory response to
treatment implies not only a worsening or prolongation of the
pathological state, but also prolonged hospitalisation, longer
withdrawal from social and active life, and waste of community
resources. Poor response to drugs has many and varied causes, among
which 4 major categories can be identified: pharmacokinetic, cellular,
genetic and medical. After a brief description of the terminology, the
phenomena of tachyphylaxis, tolerance and drug resistance are analysed
and critically described on the basis of the available evidence.
Whenever possible, alternative or operative behaviours aimed at reducing
the incidence of the above phenomena are commented on. On the question
of medical causes, irrational prescriptions and poor compliance with the
prescribed regimen stand as two major issues whose prevalence is
worrying. In order to limit the waste of professional responsibility and
economic resources, efforts aimed at reducing the present
insufficiencies are needed at organisational and educational levels.------------
I am more inclined to this interpretation.Squiggles
poster:Squiggles
thread:708634
URL: http://www.dr-bob.org/babble/20061129/msgs/709798.html