Posted by Quintal on December 23, 2006, at 22:38:29
In reply to pindolol + MAO somebody ever taken this? } Q + all, posted by sdb on December 23, 2006, at 17:04:05
> Hi Quintal,
>
> You are welcome. Thanks for your help and your input. I think you're absolutely right that some betablockers should be carefully used for people with diabetes risk such as positive family anamnesis, pathological glucose tolerance and steroid medication. You know, in Great Britain it is discussed to avoid betablockers in first line treatment in essential hypertension. There are many new meds for hypertension available such as ACE-inhibitors, AT1-antagonists, vasodilators...
> But a definitive fact is that betablockers are still widely and effectively used since many years for hypertension but many other cardiovascular disorders too.
As I said, this is the first I've heard about beta blockers increasing the risk of diabetes and I did not raise the topic, but I find it interesting nevertheless.Here is a more detailed abstract from that beta blocker study:
__________________________________________________
Drug High Blood Pressure Treatment Increases Diabetes Risk
It was traditionally believed that some drugs used to treat high blood pressure might cause diabetes. Previous research has suggested that beta-blockers and other drugs called thiazide diuretics may lead to diabetes. However the results of a new study show that beta-blockers are the only blood pressure drugs linked to the disease.Potential mechanisms by which beta-blockers may contribute to the development of diabetes include weight gain, attenuation of the beta-receptor-mediated release of insulin from pancreatic beta cells, and decreased blood flow through the microcirculation in skeletal-muscle tissue, leading to decreased insulin sensitivity.
The results are based on a study of more than 12,000 people aged 45 to 64 who did not have diabetes. At the start of the study, participants underwent a physical examination, which included blood pressure measurements and an interview about the medications they were taking.
The study also found that just having high blood pressure more than doubles a person's risk of developing type 2 diabetes, which usually begins in adulthood. Interestingly, the data from both short-term and long-term studies indicate that ACE inhibitors may actually improve insulin sensitivity and decrease the risk of type 2 diabetes.
The New England Journal of Medicine 2000;342:905-912, 969-970
http://www.mercola.com/2000/apr/2/htn_drugs_cause_diabetes.htm
__________________________________________________"Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])—Taking beta-blockers while you are taking or within 2 weeks of taking monoamine oxidase (MAO) inhibitors may cause severe high blood pressure "
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202087.html
Most sources say there is only a likelihood of increased hypotensive effect. I don't really know what to believe but with Parnate but I know I wouldn't want to take the chance unless I was under close medical supervision.
Q
poster:Quintal
thread:715894
URL: http://www.dr-bob.org/babble/20061217/msgs/716042.html