Posted by yxibow on December 24, 2006, at 4:34:30
In reply to Re: which SSRI should I add to Zyprexa » john anderton, posted by blueberry1 on December 21, 2006, at 5:07:52
> Sadly there is no predicting what add-on you would do well with. The most researched combo for zyprexa is prozac. But any ssri could do well with it. Trial and error is unfortunately the only way. With 5mg or 2.5mg zyprexa I have been on prozac and then zoloft. Both were ok, both had their own pros and cons for me.
>
> This is pure opinion and debatable, but I would start with zoloft first. The main reason is that if it doesn't work out in 1 to 4 weeks, you can immediately switch to prozac or something else, because zoloft's half life is 24 hours. If you start with prozac and it doesn't work out, it has a super long half life and will still be in your system up to a month, making any transition to another med tricky and confusing.
Zoloft also has a very mild effect on dopamine unlike the other SSRIs.I would agree with the half life issue, not to mention the harshness of Prozac being the first successful SSRI. Paxil has an even lower half life if I recall. Years ago I took Prozac but I wouldn't put it in my system any more for the reason that it can take up to 35 days to flush out of the system if you have to dump it.
-- Jay
poster:yxibow
thread:715352
URL: http://www.dr-bob.org/babble/20061224/msgs/716075.html