Posted by Tomatheus on December 24, 2006, at 18:17:13
In reply to Re: Nardil+Bupropion » tecknohed, posted by tecknohed on December 16, 2006, at 16:01:29
> My mood involves much anger & irritibility too. Is this just depression?
Tecknohed,
It's possible that the anger and irritability that you've been experiencing could be a component of your depressive disorder itself or a symptom of a comorbid anxiety disorder. If I recall correctly, I think I remember you saying that you had social anxiety disorder, so the anger and irritability could conceivably be a manifestation of either the social anxiety, depression, or both. Some researchers have also suggested that comorbid depression and anxiety can be an indication of possible bipolarity, and that patients who experience irritability along with their depressive symptoms might respond to a mood stabilizer.
Personally, nothing has ever made me more irritable than lithium did. I experienced an extreme amount of akathisia on that "mood stabilizer," as well as some other extrapyramidal side effects (most notably, the hand tremor) that are still with me today more than a year and a half after stopping the stuff. I've also read a few posts here suggesting that Lamictal could induce some irritability, but of course, responses could vary significantly from one indiviual to the next. The main point that I'm trying to make is that certain types of affective disorders may appear to resemble bipolar I and bipolar II as they're defined in the DSM, but that doesn't necessarily mean that they're going to respond to the same kind of treatment. But then again, I don't think that mood stabilizers should be completely shunned as a potential option, either.
Another thing that you might want to consider is the possibility that the Nardil that you've been taking might be contributing to the anger and irritability that you've been experiencing. Were your symptoms of anger and irritability as bad as they are now (or even present at all) before you started on your current regimen of Nardil? If not, the Nardil might be either causing these symptoms or making them worse. In general, irritability is not typically associated with Nardil use, but I have read a few reports on this board of Nardil-induced akathisia, and I know that I certainly felt irritable at times on various versions of the film-coated Nardil. So, I do think that it's possible that the Nardil *might* be playing a role in the irritability and anger that you've been experiencing.
And of course, it's also quite likely that the bupropion might be contributing to the worsening of these symptoms, especially if they've worsened since you started the drug. I'm guessing that you're probably already well aware of this possibility, but I just wanted to make sure that I covered all of my bases.
Well, I hope this helps some. Please let me know if you have any questions, and have a happy holidays.
Tomatheus
P.S. I (finally) responded the Babblemail that you sent me the other day.
poster:Tomatheus
thread:712640
URL: http://www.dr-bob.org/babble/20061224/msgs/716213.html