Posted by Tomatheus on January 9, 2007, at 8:57:28
In reply to Follow up, posted by willyee on January 8, 2007, at 11:39:30
Willyee,
Did you take Goldshield's U.K. version of Parnate (sold under the generic name tranylcypromine)? Did it differ from a version of the drug that they market elsewhere?
And I'm confused ... did you take a higher dose of Parnate than you normally take, or did you just switch from one version of Parnate/tranylcypromine to another?
I can say that I've tried taking both the U.S. version of Parnate (the brand-name product manufactured by GlaxoSmithKline) and Goldshield's U.K. version of the drug (the generic tranylcypromine that they market in the U.K.). I didn't give the GlaxoSmithKline version of Parnate anywhere close full trial because the midday sleepiness was just too much for me to handle at the time. Basically, once I started to feel that midday tranquilizing effect, I could not stay awake no matter how hard I tried and no matter how much coffee I tried to drink (and I should probably make it clear that the amount of coffee that I was consuming was at the higher end of the "moderate" range; as you probably know, consuming excessive amounts of caffeine is not recommended, especially while taking Parnate). I stopped taking the GlaxoSmithKline Parnate at 20 mg/day because of the midday sleepiness, but I think it's possible that I might have responded to a higher dose.
When I tried taking Goldshield's U.K. version of Parnate (which, as I mentioned, is sold under the generic name tranylcypromine), I noticed a definite boost in mood and energy right away. In stark contrast to the GlaxoSmithKline Parnate, the Goldshield tranylcypromine that I took (the U.K. version) did not produce any midday sleepiness whatsoever. As the case is with a lot of meds that I take, my response to the U.K. Goldshield Parnate only lasted for a few days and then immediately faded when I was taking it as monotherapy. So, I clearly did not respond to Goldshield's U.K. version of Parnate in the long term while I was taking the medication by itself, but I can say that I found that particular version of the drug to be far more potent than the GlaxoSmithKline version.
My point in comparing my responses to the two versions of Parnate is that I can certainly see how taking a high dose of Goldshield's U.K. version of Parnate/tranylcypromine could have caused you to feel the way that you did. While a dose in excess of 100 mg/day of the GlaxoSmithKline Parnate might only feel moderately activating, I can't imagine the amount of activation that such a dose of Goldshield's U.K. tranylcypromine would produce.
I'm glad to hear that you're ok. I know that I posted some information on the difference that I noticed between the Goldshield Parnate and the GlaxoSmithKline version of the drug in an older thread. However, I probably should have posted again more recently to specifically alert you to the difference that I noticed between the two formulations, considering that I'm probably one of only a few people who's ever tried taking the two versions (separately and at different times, of course).
It is theoretically possible that Goldshield's U.K. version of Parnate/tranylcypromine might not only be more potent than GlaxoSmithKline's U.S. version, but might also differ in some respects from the Parnate/tranylcypromine that the company markets in other countries. Unlike the GlaxoSmithKline version of Parnate and the generic form of the drug that's sold in the U.S., the tranylcypromine tablets that are marketed in the U.K. contain pharmaceutical glaze and carnauba wax, which give the tablets an enteric coating. Even the "old" GlaxoSmithKline version of Parnate that was manufactured until 1991 did not have that layer of protection, but it's possible that it might have dissolved more slowly in the stomach and/or intestinal tract than GSK's current version of the drug. If the tranylcypromine tablets from the U.K. had a different appearance than the Parnate/tranylcypromine pills that Goldshield markets in other countries, then it's certainly possible that the pills marketed outside of the U.K. might lack the enteric coating that the tablets sold in the U.K. possess and might thus be less potent.
At any rate, I'm glad to hear that you're doing ok right now. Please be well.
Tomatheus
> Just wanted everyone to know (well who wants to know)that although a long,very long night,i did get to sleep.
>
> I underestimated the drug because of the size,never had i seen this type,and i have seen the orignal,the U.S based generic,and one other outside.
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> It was from the same company outside,GOLDSHIELD,however the pills were flat like buttons on a kids shirt,and i again underestimated them.
>
>
> I agree with all of you,and i have taken steps prior where as the majority of my meds are with someone else,i just hold a small quantity as not to bug the person,but even this was too much to have last night,but im a grown man,well lol some will argue that ha,but i knew better.Thanks for the responses i will not make that mistake again i assure.
poster:Tomatheus
thread:720433
URL: http://www.dr-bob.org/babble/20070107/msgs/720719.html