Posted by psychobot5000 on January 10, 2007, at 21:08:35
In reply to Re: pergolide, cabergoline: heart pathology via 5-, posted by linkadge on January 10, 2007, at 8:15:18
> There was one recend study that suggested that cardiac patients who used SSRI's were more likely to die of their disease.
>
> Remember that study I just posted which showed that mice who were low in the serotonin transporter developed similar cardiac problems later in life.
>
> Depression (IMHO) is not due to altered SERT function, it is due to overactive 5-ht autoreceptors expressed in certain parts of the brain. Fixing this would have no effect on cardiac 5-ht function.
>
> Linkadge
Probably not relevant, but Tianeptine apparently improves the status of certain cardiac patients, thought from what I read this was thought to be through another pathway than serotonin receptors:"The effects of tianeptine on the glutamate-NO pathway explain the improved cardiovascular status of tianeptine-using patients with ischaemic heart disease. There is a poorly understood association between coronary heart disease and depression; disturbances in nitric oxide production may play a role in both."
__Anyway...I guess I just mean to point out that drugs can have coincidental positive effects on health as well as negative. It's not all bad!
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Clinical Efficacy of Tianeptine in Patients With Ischemic Heart Disease and Comorbid DepressionResearch Center for Preventive Medicine; Petroverigsky per., 10; 101953 Moscow, Russia
Ischemic heart disease patients (20 men, 20 women, age 36-72 years) with class II-III effort angina and depression (Beck Depression Inventory - BDI - score >= 19) were randomized to standard therapy were treatment of stable ischemic heart disease (control group) or standard therapy plus tianeptine 37.5 mg/day. After 6 weeks 52% decrease of BDI score occurred in tianeptine treated patients (from 24.9±1.2 to 11.9±1.5, p<0.001). This was associated with decrease of number and severity of cardialgias, better blood pressure control in patients with hypertension, lengthening of exercise time during exercise test (by 3.3±0.9 min, p<0.05), and increase of overall index of quality of life (by 2.6±0.9 points, p<0.01). No dynamics of these parameters occurred in control group.
poster:psychobot5000
thread:720797
URL: http://www.dr-bob.org/babble/20070107/msgs/721205.html