Posted by blueberry1 on January 15, 2007, at 15:44:49
In reply to Re: SSRIS AND ANHEDONIA, can anyone relate?? (long), posted by blueberry1 on January 15, 2007, at 5:35:22
I was reading on the web some article yesterday about Zoloft. (web...sometimes useful sometimes garbage, so what can I say)
Anyway, the article said Zoloft was the only SSRI to not blunt vigilance. And that it is good for anhedonia. They tested the time course of its therapeutic action. Anti-anxiety kicks in from day 1 to day 7. Anti-depression kicks in from day 7 to day 30. Anti-anhedonia kicks in from day 30 to day 54. Zoloft supposedly follows this pattern.
I am admittedly skeptical because plenty of people have complained about emotional numbness and sexual numbness from not only all the ssris, but Zoloft as well.
I guess what makes Zoloft different is its slight effect on dopamine and on sigma-1 receptors (though I don't know what those are). And it supposedly does not have the effect on cortisol that other ssris do.
Obviously mileage varies, and none of this stuff predicts anything.
poster:blueberry1
thread:722168
URL: http://www.dr-bob.org/babble/20070113/msgs/722584.html