Posted by yxibow on February 14, 2007, at 17:12:17
In reply to Remeron and receptors, posted by saturn on February 13, 2007, at 21:50:02
> Is it correct that Remeron first hits H1, then 5-HT2 and 5-HT3 and then later on alpha-1 NE?
>
> I'm wondering if the following might be about right:
>
> 7.5 mg---mainly H1 blocked
> 15 mg---H1 and 5-HT2/5-HT3 blocked
> 30 mg and up---H1, 5-HT2/5-HT3 and NE alpha-1 blocked?
>
> Also, does Remeron increase synaptic serotonin at all or are the serotonin effects just the 5-HT2/3 antagonism?
>
> Thanks...Peace...Saturn.
I thought the 5HT blockade occurred later on after the alpha adrenergic action which is the primary action of Remeron. But I know that the 5HT was important to me and I got up to 52.5, which was a bit too much and backed to 45. Then there was the weight....
poster:yxibow
thread:732596
URL: http://www.dr-bob.org/babble/20070213/msgs/732816.html