Posted by yxibow on March 8, 2007, at 1:36:25
In reply to Which is 'safer' - low dose Risperdal or Seroquel?, posted by nellie7 on March 5, 2007, at 11:22:40
> And is it true that Seroquel can cause thyroid problems?
> Thanks.
I haven't heard of it being common. It is a rarer issue with it, according to the PI about 0.7% experienced TSH increases that generally went away with cessation of treatment. It is dose related.
Safer... that's very hard to say... a recent study analyzed the whole atypicals and assigned I believe somewhere from 2-4% TD risk... I don't remember the citation of the study.
There was also a study of Zyprexa by a British journal which analyzed a number of patients and assigned a risk of 0.5% per year potentially for TD.
Some say very low Risperdal actually increases D2, which is an antithesis to treatment. I don't know if that is true in real practice or not. Risperdal did strange things to my dreams and permanently affected my right index finger with a Prozac combination that has never quite stopped twitching at nearly undetectible rate. But then I still take an antipsychotic for non psychotic reasons -- Seroquel, which has some pseudoparkinsonism, so its hard to say.
If you extrapolated from the Zyprexa, Seroquel, being a weaker agent, might be assigned say with a 0.25% rate of TD.
But its unknown overall. I would say that the lower down the totempole of atypicals that one can stand and is useful and overall regardless which one, the lower the dose, is always the safest thing. It is recommended by Wirshing et alia, that the MED (minimum effective dose) of an antipsychotic be used.The days of dialing up Haldol until you reached sheer EPS and then it was effective are a past fantasy.
poster:yxibow
thread:738480
URL: http://www.dr-bob.org/babble/20070302/msgs/739131.html