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Re: Dopamine Agonists

Posted by linkadge on March 31, 2007, at 14:27:38

In reply to Re: Dopamine Agonists » linkadge, posted by Quintal on March 31, 2007, at 14:12:03

>I was just thinking of amineptine actually, it >wasn't associated with the kind of euphoria >Ritalin and amphetamines usually produce
>(although it did have abuse potential). I'm >starting to associate high dopamine with mellow >contentment than speedy euphoria, but perhaps a >sudden increase in dopamine can cause a 'rush'? >It seems that most of the euphoric dopaminergic >drugs bar opiates are also powerful NA reuptake >inhibitors.

This is it. Most drugs are not clean enought to make inferences about a particular mechanism.


>I'm thinking of experimenting with adding a NRI >agent to see if that helps focus and motivation. >I have reboextine and sibutramine and I'm >thinking sibutramine might have additional >benefits on the serotonin system, but it's also >a little 'messier' than reboextine. I think I'll >try reboxetine first, is there any interaction >info/problems between these drugs?

Not that I know of.


>Is it possible to create a dopamine agonist that >binds directly to receptors in the nucleus >accumbens? I want one!

I'm sure its possable. Thought I don't know how the brain would respond long term.

Linkadge


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