Posted by Quintal on April 6, 2007, at 14:57:50
In reply to Re: Best meds for anhedonia » Quintal, posted by falconman on April 6, 2007, at 12:40:03
No, you don't have to take more than the therapeutic dose of either paracetamol or ibuprofen to get 20-40mg of codeine, but it depends on the brand you use. I use Paramol which contains 7.46 mg dihydrocodeine. Dihydrocodeine is about 1.5x as potent as codeine, so you get roughly 22mg equivalent of codeine from the recommended two tablets if my math is correct. I sometimes add Nurofen Plus which contains 12.8mg codeine per tablet, so in total I can get the equivalent of roughly 47mg codeine from that cocktail if I take the two tablets of each brand.
It is safe to take paracetamol and ibuprofen together - I was started on this cocktail for pain control after being discharged from hospital. I'm sure there are risks to it, but probably no more so than with any other drug cocktail recommended here for anhedonia.
Yes, SSRIs are CYP2D6 inhibitors which can reduce or eliminate the effect of codeine because CYP2D6 converts codeine into morphine - the metabolite apparently responsible for most of the therapeutic effect.
Q
poster:Quintal
thread:747289
URL: http://www.dr-bob.org/babble/20070402/msgs/747581.html