Posted by Larry Hoover on April 21, 2007, at 13:26:01
In reply to Drugs metabolized by the liver, posted by Squiggles on April 21, 2007, at 12:20:36
> Clonazepam is metabolized by the liver.
>
> My friend has been getting foggier and
> more confused since clonazepam was introduced (3.0mg - i suggest 2.0 and now she's more
> alert but still slammed into sleep after taking 2.0mg), She also takes imipramine (now 250mg), which i do not know if that is metabolized by the liver.
>
> The intoduction of clonazepam happened after/around the time Serzone was tried on her, which was discontinued after a few months. I thought that perhaps the serzone screwed up the liver, but the docs. did not think that was it.
>
> There is no doubt however, that after taking clonazepam, she falls into bed into a comatose-like sleep.
>
> Whazzup?
>
> SquigglesFrom drugs.com:
"Interactions between your selected drugs
clonazepam and imipramine (Moderate Drug-Drug)MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking clonazepam and tricyclic antidepressants. However, one case report has described decreased desipramine levels during concurrent administration with clonazepam. The mechanism is unknown.
MANAGEMENT: Patients should be monitored for excessive or prolonged CNS and respiratory depression. Ambulatory patients should made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, or confusion) and counseled to avoid activities requiring alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities."
The Serzone didn't permanently affect the liver, or your friend's doctors would have been all over it.
A similar interaction exists between Serzone and clonazepam, though. Your friend should be reporting this excess sedation to her doctor. The dose still seems too high, *for her*. Comatose is not a good reaction.
Lar
poster:Larry Hoover
thread:744916
URL: http://www.dr-bob.org/babble/20070419/msgs/752022.html